Treatments for Multiple Sclerosis (MS)

Treatments for Multiple Sclerosis (MS)CHAPTER 5 TREATMENTAs we hold back read previously, clinic totallyy disjunct syndrome may develop to tenfold sclerosis and beca manipulation there is no way of determining whether an individual will undergo to develop MS afterward having an episode of demyelination, making the decision to treat and monitor the ongoing changes very difficult.Evidence have suggested that the preliminary the start of disease modifying operators in the early course of MS the more effective they atomic number 18. There ar numerous studies have indicated that starting disease modifying agents after clinically detached syndrome delays the onset of MS, but these studies dust controversial.There have been arguments whether or not to start disease modifying agents after a clinically isolated syndrome. Those who support the start of these agent sideline diagnosis of CIS cite the results of some clinical trials that shows that these drugs reduce the find of de veloping to MS by one third. A treat all early approach have been proposed as vanquish to ensure all people who would go on to developing MS do receive the word .The other side of this argument have existing evidence for the disease modifying agent in MS shows only sensory systemst short term effectiveness in high danger of infection cases of CIS. Treatment is unnecessary for those who would never gone on to developing MS after CIS.Four giant clinical trials have been conducted to determine whether early treatment fol mooing an episode of CIS basis delay the second clinical episode, and therefore the diagnosis of clinically definite MS5.1 Controlled High-Risk Subjects Avonex MS Prevention determine (CHAMPS)The goals of the landing field arThe early induction interferon of import-1a (AVENOX ) treatment can delay the 2nd episode of demyelination which in turn can signal definite MSIf the treatment would have any benefits on magnetic resonance imaging detected brain lesion s.Subjects have in this study had experienced a single episode of isolated neurological event suggesting demyelination and had ninefold clinically silent magnetic resonance imaging lesions, which they represent a high risk for a second neurological attack (definite MS) (40, 41).The results indicated that AVENOX (interferon beta-1a) had significantly delay the 2nd neurological attack, and MRI purpose showed that AVENOX can decrease the volume of brain lesions and as well as fewer lesions . Based on this study, the FDA approved that patients with clinically isolated syndrome with MRI detected brain lesions to receive AVENOX .figure(2).(40)(42)Figure (2) impact of interferon beta following first neurological attackSourcehttps//quo.novartis.com/extavia/images/extavia_EFFICACY1_banner.jpg5.2 Early Treatment Of MS ( ETOMS )The goals of the study areDetermine if very low doses of interferon beta 1a (REBIF) delays the onset of clinically definite six-fold sclerosis in people who experien ced only one clinical event but had multiple MRI lesions (43,44).Results indicated thatThe classify of people who received interferon beta-1a (REBIF) who authentic clinically definite MS (34%) is fewer than the theme of people receiving placebo (45%) during the period of the study.(45)The number of sassy lesions has decreased in the treatment group and the demyelination areas is significantlylower.figure(3).(45)Figure (3 ) condensing between the groups receiving REBIF and placeboSourcehttp//dailymed.nlm.nih.gov/dailymed/archives/image.cfm?archiveid=100714type=imgname=rebif-01.jpg5.3 Betaseron In Newly Emerging MS For Initial Treatment (BENEFIT)The goals of the studyDetermine if interferon beta-1b can delay the onset of clinically definite MS in subjects with first clinical sign of MS or CIS who are at a high risk for developing MS (46).ResultsAt day 255 of the study, one quarter of the subjects in the placebo group had developed clinically definite MS. In the other hand, it too k 618 days for approximately same number of subjects in the treatment group to develop clinically definite MS. (47)After the two years study, it was determined that 28% of the subjects under the treatment group had developed clinically definite MS compared to the 45% of the placebo group (47)The FDA has approved that patients who have experienced CIS and have MRI feature consistent with MS to receive the treatment with Betaseron figure (4).Figure (4) comparison between Betaseron receiving group and placebo groupSourcehttp//www.iodine.com/label-content/261fde67-efb2-4bd7-947e-4f68a56e76ff-c71a5c99d2acf2ddb0e66c9266460f4c.jpg5.4 The pre-CIS studyStudy goalsDetermine the period of period it takes for subjects diagnosed with clinically isolated syndrome receiving glatiramer ethanoate rayon ( Copaxone ) to develop a second attack that would confirm the diagnosis of definite MS.Results indicated that the group who received glatiramer acetate in comparison with the placebo group, has sig nificantly reduced the risk of developing clinically definite MS.Based on these results, the FDA has indicated to that individuals who have had first clinical episode and MRI feature consistent with MS to receive copaxone as treatment.Based on these trials , it have been approved the necessity of starting treatments as soon as likely for clinically isolated syndrome patients and those who have first clinical episode and MRI evidence suggestive of multiple sclerosis (48).The interferons agents should be used with high cautions by depressed patients or individuals with history of depression because of some evidence indicated that these meds may progress the depression symptoms. In patients with depression the physician should give best possible treatment decision to not worsen the depression episodes and in same time have arrogant effects in the case of treatment purpose (49).5.5 Interferon beta medicationAvonex (interferon beta- 1a) it has been shown in the previous clinical trial s to reduce the frequency of relapses in MS and the number of the new lesions on MRI, and it alike reduces the disease progression. It has been excessively shown that Avonex reduces the risk to develop MS in clinically isolated syndrome at high risk patients.Uses CIS and backsliding forms of MS (secondary progressive MS).Dosage 30 micrograms once a week IM nip.Side effect flue-like symptoms following the injectants, depressions, anemia, elevated liver enzymes and liver toxicity.Betaseron (interferon beta-1b) in the previous clinical trials, betaseron has shown that it reduces the frequency and severity of relapses. In addition, it also showed that it reduces the number of new lesions or even active lesions on MRI. Like Avonex, betaseron have also the index to delay the onset of MS in people with CIS and has been approved by the FDA for this use specifically.(50)Uses CIS and relapsing forms of MS ( secondary progressive MS )Dosage 250 micrograms once every two days subcutan eous injectionSide effects flue like symptoms after injections, injection site reaction, depression, elevated liver enzymes and low white blood cells counts.Rebif (interferon beta-1a) has shown to reduce the frequency, relapses and the number of new / active lesions on MRI. Like avonex and betaseron, rebif has demonstrated that it can delay the onset of MS in patients with CIS. But, unfortunately it have not been approved by the FDA for this use yet. (51)Uses CIS and relapsing forms of MS ( secondary progressive MS )Dosage 20 micrograms every day subcutaneous injectionSide effects flue like symptoms after injections, injection site reaction, depression, elevated liver enzymes and low white blood cells counts.Copaxone (glatiramer acetate) in addition to interferon beta drugs, Copaxone has shown to reduce frequency of relapses and the number of new/active lesions on MRI scan. Its been used in relapsing remitting type of multiple sclerosis. Until the present, the mode of action have not been discovered. Some theories have been suggested but no scientifically proven hypothesis is discovered.(51)Uses CIS and relapsing remitting forms of MSDosage 44 micrograms 3 times a week subcutaneous injectionSide effects injection site reactions, a reaction after injection, anxiety, chest tightness, dyspnea and flushing.In conclusions, there is no definite treatment of multiple sclerosis or clinically isolated syndrome in the presence of demyelination of the central nerve system. But, reducing the amount of the lesions, frequency of the episodes and prolonging the period of developing MS in high risk patient is the goals we are looking for.CIS can be difficult to diagnose or to determine whether or not to start the treatment, and the physician may find a hard time to find the best decision in these cases keeping in mind that the sooner the beginning of the treatment the less progressive the disease is (52).5.6 PreventionGiven to the heterogeneous etiological factors and of ten idiopathic distinction of CIS, there are no clear means of prevention exists. In postinfectious patients with CIS, prevention of the infection is the best means of prevention. In acute disseminated encephalomyelitis, almost 70% of cases are associated with infections and 5% (approximately) with vaccination. acute disseminated encephalomyelitis rates are estimated with 1.5 per millions (2 per million) in association with live measles vaccine compared to 1 in 1000 risk of postinfectious fruit drink with measles infections, suggesting that vaccines may decrease the risk of post infection complications. Unfortunately, vaccines are not available for all bacteria and viruses (53).